![]() ![]() However, the mode of action of the most promising antifungal compounds was assessed by docking with cytochrome P450 14 α-sterol demethylase (CYP51) (PDB ID: 1EA1).Ĭompound 4a showed good inhibitory activity against both C. The antifungal activity of the newly synthesized compounds was evaluated against two strains of fungi, namely, Candida albicans (ATCC-10231) and Aspergillus niger (ATCC-10535). New series of thiadiazoles 4a-c, morpholinyl-acetamides 6a-c, 4-methylpiperazinylacetamides 7a-c, thiazolidines 10a-c, azetidines 12a-c - 13a-c, sulfonamides 14a-c - 15a-c, benzamides 16a-c, pyrrolidines 17a-c, succinamic acids 18a-c, acetamides 19a-c, thieno(2,3- c)pyridines 20a-c, thieno(2,3- e)-1,2,4-triazolo(1,5- c)pyrimidines 23a-c, thieno(2,3- d) pyrimidines 24a-c - 26a-c, and thieno(2,3- b)pyridines 27a-c derivatives incorporated into N-substituted 3-indolylthiophenes were prepared by an initial reaction of 2-amino-4-( N-substituted-1 H-indol-3-yl)thiophene-3-carbonitriles 1a-c with different reagents. The present work aimed to synthesize new 3-indolylthiophene derivatives and evaluate their antifungal activity by studying their molecular docking. ![]() Thus, development of new antifungal agents with less toxicity is urgently required. The currently available antifungal drugs have the limitations of toxicity, potential drug interaction with other drugs, insufficient pharmacokinetics properties, and development of resistance.
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